Introduction to Cell Mechanics and Mechanobiology is designed for a one-semester course in the mechanics of the cell offered to advanced undergraduate and graduate students in biomedical engineering bioengineering and mechanical engineering. It teaches a quantitative understanding of the way cells detect modify and respond to the physical properties within the cell environment. Coverage includes the mechanics of single molecules polymers polymer networks two-dimensional membranes whole-cell mechanics and mechanobiology as well as primer chapters on solid fluid and statistical mechanics and cell biology. Introduction to Cell Mechanics and Mechanobiology is the first cell mechanics textbook to be geared specifically toward students with diverse backgrounds in engineering and biology.